Denver Broncos Face Arizona Cardinals in Week 7 Matchup

The Denver Broncos travel to Glendale, Arizona, to face the Arizona Cardinals in an NFL Week 7 regular-season matchup at State Farm Stadium on Sunday, October 25, 2026. Kickoff is scheduled for 4:05 p.m. ET, with the game broadcast nationally on CBS.

Denver enters the contest with a 4-2 record and a two-week winning streak, including a 17-14 overtime victory against the Seattle Seahawks. The Broncos have relied heavily on a stout defense that is allowing just 20.8 points per game and ranks among the league leaders with 18 sacks. Offensively, quarterback Bo Nix has recorded 1,049 passing yards and six touchdowns through six games, though the team is averaging 19.0 points per contest.

The Arizona Cardinals host the game with a 2-4 record, looking to build momentum after securing an 18-16 win against the Los Angeles Rams last week. Quarterback Jacoby Brissett leads the Cardinals' offense with 1,328 passing yards and nine touchdowns. Arizona averages 21.0 points per game but has struggled defensively, allowing 29.7 points per contest and ranking 31st in the league in scoring defense.

Both teams enter the matchup dealing with significant personnel absences. The Broncos ruled out star cornerback Patrick Surtain II as a precautionary measure due to a questionable status, opting to give him additional recovery time with safety Taylor Rapp elevated from the practice squad. Meanwhile, the Cardinals will be without running back Jeremiyah Love and defensive lineman Walter Nolen III, giving players like Tyler Allgeier increased opportunities in the backfield.

Betting markets list the Broncos as 4.5-point road favorites, with the Over/Under set at 42.5 points. Denver has compiled a 4-2 record against the spread this season and is 3-0 as a favorite. Conversely, the Cardinals are seeking their first home victory of the season after dropping their first two games in Glendale and struggling historically at home over the past year.

As both squads prepare for kickoff, the game is expected to hinge on whether Denver's disruptive pass rush can pressure Brissett and limit big plays, or if the Cardinals can establish an effective offensive rhythm to pull off the home upset.